Effect of Melatonin on some Biochemical Parameters in D-galactose Induced Aging in Rats

The current research investigates the main physiological and potent antioxidant roles of melatonin hormone in induced aging rats by D-galactose administration. This research includes 4 groups of male rat, Group 1:considered as a control group administered distilled water, Group 2: D-galactose induced aging by administration of (300mg/kg B.Wt .S.C.) for 15 weeks, Group 3: administered melatonin hormone (10 mg/kg B.wt. orally) for 15 weeks, Group 4: induced aging by D-galactose (300mg/kg B.wt .S.C.)+melatonin hormone (10 mg/kg B.wt. orally) for 15 weeks. Results Body and brain weight is decreased in the induced aging rats. Advanced glycation end products (AGEs), Advanced oxidation protein products (AOPP) andthiobarbituric acid reactive substances (TBARS) is increased significantly in the D- galactose aged rats compared with control group accompanied with significant decrease in Superoxide dismutase (SOD) and Glutathione (GSH) level induced aging rats compared with control rat group. Melatonin hormone could effectively attenuates these alterations. conclusion: melatonin hormone administration counteracted the accelerated induced aging process by D-galactose in rats which may be due to its effects on antioxidant enhancing activity and protect the cell from lipid and protein oxidation. Keywords: Aging, D- galactose, Melatonin hormone.