Synthesis and Biological Activity of some New Nitrogenous Heterocyclic Compounds Derived from Azachalcone

A series of heterocyclic compounds containing oxygen and nitrogen atoms, isoxazoline I(a-d) and another containing two nitrogen atoms, pyrazolinesII(a-d) and phenylpyrazolines IV(a-d) were prepared by the reaction of a proper azachalcones (a-d) with hydroxylaminehydrochloride, hydrazine hydrate or phenylhydrazine. These heterocyclic compounds were characterized by 1H-NMR , CHN , IR and UV spectra in addition to their some physical properties. Also, these prepared compounds were screened for their biological activities and a theoretical calculation which shows that the product IVa obtained from 1,2 rout was energetically more stable by 1.3967 kcal/mole than that came from 1,4 rout, thus the reaction proceed via 1,2 addition 1,2)).