The Effect of Using Nanoparticles Titanum Dioxied to Control of Secondary Infection of Echinococcus granulosus In vivo

Current study covered the effect of titanium dioxide nanoparticles (TiO2) size 10 and 250 nm, using 3 mg/ ml for month and two months for each size. TiO2 used against secondary infection in rats strain Rattus norvegicus, where administrated by 2000 protoscolices treated with each size of TiO2. Above treated animals compared with other left free with any treatments as a negative control and other animals just treated with protoscolices as a positive control. The effect of protoscolices and TiO2 mixture were revealed a reduction in rate of infection by 100% for each size 10 and 250 nm TiO2 and for each period month and two months. Histological changes in each of liver and intestine have studied. Several pathological changes including focal aggregation of inflammatory cells and mild chronic inflammation for TiO2 size 10 nm were noted, while fibrosis and nicrosis were noted at 250 nm of TiO2. These results gave important sigs that small size of TiO2 may be work as a good antigrowth for developing secondary hydatidosis.