Biochemical Study of Omentin-1 in Breast Cancer Patients of Mosul City-Iraq

Background: Breast cancer is one of the most common malignancies diagnosed in women, and its incidence is increasing every day. Omentin-1 is a new class of adipocytokine expressed in the intestines, vascular tissue, visceral adipose tissue, and goblet cells of the respiratory system. Researchers have demonstrated that omentin-1 plays a critical role in the processes of carcinogenesis.
Aim: To evaluate the levels of serum omentin-1, aromatase, other hormones, and enzymes of patients women with breast cancer in Mosul City. Also, biotechniques will study omentin-1 of normal human plasma.
Methods: This study comprised 50 patients at the beginning of diagnosis with breast cancer and follow-up after surgery by one month from the same ones in addition to 50 healthy women as control samples with ages between (25 and 75) years. The samples were classified into pre and postmenopausal women. Samples were collected from October 2023 to March 2024.
Results: Omentin-1 and other variables levels in breast cancer affected before or after menopause. Also, from biochemical techniques, the results indicated that omentin-1 has a low molecular weight of nearly 39810 Dalton with specific activity (5.25 ) and recovery (70%) with purification folds (40.38).
Conclusion: Breast cancer is affected by many factors, such as menopause, family history, old age as well as obesity. The concentration of Omentin-1 as adipokine is influenced by many types of cancer, such as breast cancer. It has been observed that postmenopausal women with breast cancer have high aromatase activity and thus increase the level of estradiol, which in turn can interact with its metabolites with DNA to cause carcinogenic mutations, which contribute to the development of breast cancer.