New Metal Complexes of 2-(3-(4-Nitrobenzoyl)Thioureido)Benzoic Acid, Synthesis and Characterization (NTB)

Section: Article
Issue
Vol. 35 No. 1 (2026): Volume 35, Issue 1
Published
Jan 1, 2026
Pages
75-84

Abstract

The presence of a drive site within ligand structures plays a crucial role in enhancing their interaction with metal ions, resulting in highly efficient complex formation research. A new ligand, 2-(3-(4-nitrobenzoyl) thioureido) benzoic acid (NTB), was successfully synthesized via the reaction of 4-nitrobenzoyl isothiocyanate with anthranilic acid in a 1:1 molar ratio. The structure of the ligand was confirmed using elemental analysis, FT-IR, UV-Vis., and ¹H and ¹³C NMR spectroscopy. Then a series of metal complexes was synthesized by reacting NTB with divalent metal ions, including Hg²⁺, Cd²⁺, Zn²⁺, Cu²⁺, Ni²⁺, Co²⁺, and Mn2+. The analytical results suggest that all metal complexes adopt a tetrahedral geometry, except for the copper complex, which exhibits a square planar structure. The metal-to-ligand ratio in all complexes was determined to be 1:2, supporting the proposed [M(NTB)₂] formulation.

References

  1. M. Nawaz et al., “Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies,” BMC Chem, vol. 16, no. 1, 2022, doi: 10.1186/s13065-022-00817-x.
  2. A. A. Ahmed, S. A. Musa, M. B. Fugu, A. I. Mohammed, H. B. Adam, and I. M. Wakil, “A Comprehensive Review on Anthranilic acid-derived Schiff bases and their Metal chelates: Structures and Applications,” 2023. doi: 10.22034/crl.2023.401158.1227.
  3. P. Marinova and M. Hristov, “Synthesis and Biological Activity of Novel Complexes with Anthranilic Acid and Its Analogues,” 2023. doi: 10.3390/app13169426.
  4. J. Strachan, C. Barnett, A. F. Masters, and T. Maschmeyer, “4-Nitrophenol Reduction: Probing the Putative Mechanism of the Model Reaction,” ACS Catal, vol. 10, no. 10, 2020, doi: 10.1021/acscatal.0c00725.
  5. A. Frei et al., “Metal Complexes as Antifungals? from a Crowd-Sourced Compound Library to the First in Vivo Experiments,” JACS Au, vol. 2, no. 10, 2022, doi: 10.1021/jacsau.2c00308.
  6. M. Samsonowicz, E. Regulska, and M. Kalinowska, “Hydroxyflavone metal complexes - molecular structure, antioxidant activity and biological effects,” 2017. doi: 10.1016/j.cbi.2017.06.016.
  7. M. Bouhdada, M. EL Amane, B. B. Mohammed, and K. Yamni, “Synthesis, spectroscopic studies, X-ray powder diffraction data and biological activity of mixed transition metal complexes with oxalato and theophylline ligands,” J Mol Struct, vol. 1177, 2019, doi: 10.1016/j.molstruc.2018.09.047.
  8. M. Gacki, K. Kafarska, A. Pietrzak, I. Korona-Głowniak, and W. M. Wolf, “Double palindrome water chain in cu(II) theophylline complex. synthesis, characterization, biological activity of cu(II), zn(II) complexes with theophylline,” Crystals (Basel), vol. 10, no. 2, 2020, doi: 10.3390/cryst10020097.
  9. M. Nawaz et al., “Synthesis, spectral studies and biological evaluation of 2-aminonicotinic acid metal complexes,” Spectrochim Acta A Mol Biomol Spectrosc, vol. 161, 2016, doi: 10.1016/j.saa.2016.02.022.
  10. S. N. Sovari and F. Zobi, “Recent Studies on the Antimicrobial Activity of Transition Metal Complexes of Groups 6–12,” 2020. doi: 10.3390/chemistry2020026.
  11. J. O. Adeyemi and D. C. Onwudiwe, “Chemistry and some biological potential of bismuth and antimony dithiocarbamate complexes,” 2020. doi: 10.3390/molecules25020305.
  12. Y. Yang, G. Liao, and C. Fu, “Recent advances on octahedral polypyridyl ruthenium(II) complexes as antimicrobial agents,” 2018. doi: 10.3390/polym10060650.
  13. M. Gacki, K. Kafarska, A. Pietrzak, I. Korona-Glowniak, and W. M. Wolf, “Synthesis, characterisation, crystal structure and biological activity of metal(II) complexes with theophylline,” Journal of Saudi Chemical Society, vol. 23, no. 3, 2019, doi: 10.1016/j.jscs.2018.08.006.
  14. M. Litecká et al., “Toxic metal complexes of macrocyclic cyclen molecule–synthesis, structure and complexing properties,” J Coord Chem, vol. 70, no. 10, 2017, doi: 10.1080/00958972.2017.1305493.
  15. B. S. Journal, “Synthesis and Characterization of Some New Metals Complexes of [N-(4-Nitrobenzoyl Amino)-Thioxomethyl] Phenylalanine,” Baghdad Science Journal, vol. 13, no. 1, 2016, doi: https://doi.org/10.21123/bsj.2016.13.1.0113. . Basima M. Sarhan, Mohammed A. Al-karboly, Dena H. Zaidan
  16. Y. Chen, J. L. She, L. Tang, Y. H. Liu, and X. F. Zhou, “Research progress of nitrobenzoyl sesquiterpenoids as marine characteristic natural products,” Yaoxue Xuebao, vol. 59, no. 1, 2024, doi: 10.16438/j.0513-4870.2023-0419.
  17. T. Widiandani, B. T. Purwanto, and Siswandono, “THE POTENCY OF 4-NITROBENZOYL-3-ALLYLTHIOUREA AS AN AGENT OF BREAST CANCER WITH EGFR/HER2: IN SILICO AND IN VITRO STUDY,” Rasayan Journal of Chemistry, vol. 15, no. 3, 2022, doi: 10.31788/RJC.2022.1536976.
  18. B. Maeda and K. Murakami, “Recent advancement in the synthesis of isothiocyanates,” Chemical Communications 2024, 60, 2839-2864.. doi: 10.1039/d3cc06118c.
  19. A. G. Németh and P. Ábrányi-Balogh, “Recent advances in the synthesis of isothiocyanates using elemental sulfur,” 2021. doi: 10.3390/catal11091081.
  20. T. D. Moseev et al., “Co(II), Cu(II), and Mn(II) complexes based on 2,2’-bipyridine and 3-(2-pyridyl)-1,2,4-triazine ligands containing organofluorine species,” Inorganica Chim Acta, vol. 558, 2023, doi: 10.1016/j.ica.2023.121727.
  21. N. Azad, “UV-visible spectroscopy,” in Analytical Methods in Chemical Analysis: An Introduction, 2023. doi: 10.1515/9783110794816-004.
  22. D. M. H. Al-Mudhaffar, D. S. Al-Edani, and S. M. Dawood, “Synthesis, characterization and biological activity of some complexes of some new amino acid derivatives N-[(benzoyl amino)-thioxomethyl]-amino acid(HL),” Journal of the Korean Chemical Society, vol. 54, no. 5, 2010, doi: 10.5012/jkcs.2010.54.5.506.
  23. B. Ren, “Fundamental and Applied Reviews in Analytical Chemistry,” 2022. doi: 10.1021/acs.analchem.1c05291.
  24. A. B. P. Lever and S. A. Rice, “ Inorganic Electronic Spectroscopy ,” Phys Today, vol. 22, no. 10, 1969, doi: 10.1063/1.3035225.
  25. M. Romero, D. Mombrú, F. Pignanelli, R. Faccio, and A. W. Mombrú, “Mini-Review: Mixed Ionic–Electronic Charge Carrier Localization and Transport in Hybrid Organic–Inorganic Nanomaterials,” 2020. doi: 10.3389/fchem.2020.00537.

Author

Dena H. Zaidan

Department of Chemistry, College of Education for Women, University of Al-Anbar, Al-Anbar, Iraq

Identifiers

https://doi.org/10.33899/jes.v35i1.60279
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[1]
D. H. . Zaidan, “New Metal Complexes of 2-(3-(4-Nitrobenzoyl)Thioureido)Benzoic Acid, Synthesis and Characterization (NTB)”, JES, vol. 35, no. 1, pp. 75–84, Jan. 2026.
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