Evaluation of the Role of some Myokines and Tumor Necrosis Factor-Alpha in Women with Polycystic Ovary Syndrome in Mosul City-Iraq

Polycystic ovary syndrome (PCOS) is considered one of the endocrine disorders common in females of reproductive age. The study aims to evaluate the role of some myokines (hormones follistatin and irisin) among the causes of infection, tumor necrosis factor-alpha (TNF-) is one of the inflammatory cytokines and is considered a primary indicator of inflammation in women infected with PCOS. The study included 75 blood samples, drawn from 50 married women (25 primary infertility, 25 secondary infertility) and 25 single women infected with PCOS, whose ages ranged between (15-45) years, collected from Al-Batoul Teaching Hospital in Nineveh Governorate, after they were diagnosed by obstetricians, gynecologists and infertility doctors. As well as 50 blood samples from women (25 married and 25 single) who were healthy and did not infect with PCOS and of the same ages were considered as a control group. Determination of follistatin, irisin and TNF- in serum using kits based on the ELISA-sandwich principle.The results showed a significant increase in follistatin, irisin and TNF- levels in serum of both married and single women infected with PCOS, and in infected married women with primary and secondary infertility compared with the control. We conclude that follistatin and TNF- are linked to the inflammatory state of women infected with PCOS, and irisin can be considered a biomarker to detect this syndrome.