Comparison Study between Oat Seeds Powder and Simvastatin Drug on some Hormones and Histological Features of Aorta and Liver in Healthy and Ovariectomized White Female New Zealand Rabbits

The results showed positive effects as a significant increase (P0.0001) in Adiponectin hormone with significant decrease in Leptin hormone in rabbit's serum that given oat seeds powder and also those treated with simvastatin drug, and insignificant increase in Estrogen hormone in this two groups compared with control group in contrast there is a negative effects as a significant decrease in Adiponectin hormone and Estrogen hormone concentration in ovariectomized rabbit's serum with significant increase in Leptin hormone concentration, while tend in ovariectomized rabbits given oat seeds powder to be in near with normal concentration in control, and ovariectomized rabbits group given simvastatin showed either significant or insignificant near with normal concentration in control. Experimental atherosclerosis by ovariectomy in females led to negative effects on biochemical criteria of blood serum as compared with control group, which was represented by significant increase in the concentration of Total Cholesterol (TC) and Low Density Lipoprotein-cholesterol (LDL-c), beside significant decrease in High Density Lipoproteins-cholesterol (HDL-c) and Paraoxonase enzyme (PON-1), in general treated rabbits with oat seeds powder led to positive willful for all precedent parameters. Histological sections of aorta artery in ovariectomized rabbits showed atherosclerotic lesions between the muscle fibers in media of aorta in contrast with the normal structure of aorta in rabbits in control group. Ovaiectomy led to negative effects on histological features of healthy and overectomized rabbit's liver. .