Relationship of nesfatin-1 to insulin resistance and sensitivity indices in patients with myocardial infarction

Nesfatin-1 was discovered in 2006 as a polypeptide containing 82 amino acids and has multiple metabolic effects due to its wide distribution in central and peripheral organs. In this study, we investigated the relationship between serum nesfatin-1 levels and insulin resistance and sensitivity indices (HOMA-IR) in patients with myocardial infarction. The study included 158 participants aged (35-75 years) of both sexes and they were divided into two groups: (83) patients with myocardial infarction and (79) healthy individuals. The levels of nesfatin-1, glucose, insulin, and insulin resistance and sensitivity indices were measured for both groups. The results showed a significant decrease in the level of nesfatin-1 in patients with myocardial infarction compared to the control group. There was also a significant increase in the concentration of insulin, glucose and insulin resistance indices (HOMA-IR, TYG, FIGR, FIRI) and a significant decrease in insulin sensitivity indices (McCauley’s index, QUICKI, Raynaud’s index